Roger J Hajjar Selected Research

Sarcoplasmic Reticulum Calcium-Transporting ATPases

1/2019	Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca2+-ATPase in Heart Failure.
1/2019	Role of the PRC2-Six1-miR-25 signaling axis in heart failure.
11/2017	Effect of intracoronary administration of AAV1/SERCA2a on ventricular remodelling in patients with advanced systolic heart failure: results from the AGENT-HF randomized phase 2 trial.
6/2015	Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure.
11/2014	The role of SUMO-1 in cardiac oxidative stress and hypertrophy.
1/2014	Long-term effects of AAV1/SERCA2a gene transfer in patients with severe heart failure: analysis of recurrent cardiovascular events and mortality.
8/2013	Cardiac surgical delivery of the sarcoplasmic reticulum calcium ATPase rescues myocytes in ischemic heart failure.
7/2013	Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension.
7/2013	Benefit of SERCA2a gene transfer to vascular endothelial and smooth muscle cells: a new aspect in therapy of cardiovascular diseases.
2/2013	Gene therapy for heart failure: where do we stand?

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Roger J Hajjar Research Topics

Disease

101	Heart Failure 08/2021 - 01/2002
30	Myocardial Infarction 01/2020 - 09/2002
27	Fibrosis (Cirrhosis) 01/2020 - 08/2007
18	Hypertrophy 05/2019 - 06/2007
17	Cardiomegaly (Heart Hypertrophy) 08/2021 - 01/2002
15	Infarction (Infarctions) 01/2019 - 01/2007
14	Heart Diseases (Heart Disease) 08/2021 - 09/2002
13	Ischemia 01/2019 - 09/2002
9	Cardiomyopathies (Cardiomyopathy) 02/2022 - 09/2002
7	Cardiovascular Diseases (Cardiovascular Disease) 05/2015 - 05/2007
6	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2020 - 12/2002
5	Pulmonary Hypertension 01/2022 - 01/2018
5	Hypoxia (Hypoxemia) 01/2020 - 10/2014
5	Vascular Remodeling 01/2020 - 07/2013
5	Cicatrix (Scar) 01/2018 - 05/2011
5	Inflammation (Inflammations) 01/2018 - 03/2007
5	Ventricular Remodeling 03/2016 - 08/2007
4	Cardiac Arrhythmias (Arrythmia) 02/2022 - 02/2007
4	Ventricular Tachycardia 02/2022 - 12/2015
4	Insulin Resistance 10/2018 - 08/2008
4	Diabetic Cardiomyopathies 10/2018 - 05/2006
4	Reperfusion Injury 03/2016 - 03/2007
4	Infections 05/2011 - 06/2004
3	Necrosis 01/2019 - 03/2007
3	Type 2 Diabetes Mellitus (MODY) 01/2019 - 02/2007
3	Obesity 10/2018 - 08/2008
3	Body Weight (Weight, Body) 03/2016 - 11/2004
3	Mitochondrial Diseases (Mitochondrial Disease) 07/2015 - 12/2004
3	Coronary Artery Disease (Coronary Atherosclerosis) 05/2011 - 09/2002
2	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2020 - 10/2017
2	Thrombosis (Thrombus) 01/2019 - 01/2007
2	Myocardial Ischemia (Ischemic Heart Diseases) 01/2019 - 03/2013
2	Hypertension (High Blood Pressure) 01/2018 - 05/2011
2	Pulmonary Arterial Hypertension 01/2018 - 07/2013
2	Cardiac Sudden Death (Sudden Cardiac Arrest) 03/2017 - 01/2008
2	Atherosclerosis 11/2014 - 03/2011
2	Neointima 10/2014 - 09/2005
2	Stroke (Strokes) 09/2013 - 01/2008
2	Ventricular Dysfunction 08/2012 - 02/2006
2	Neoplasms (Cancer) 04/2011 - 06/2008
2	Neoplasm Metastasis (Metastasis) 11/2010 - 06/2008

Drug/Important Bio-Agent (IBA)

40	CalciumIBA 10/2021 - 01/2002
25	Proteins (Proteins, Gene)FDA Link 10/2021 - 01/2002
21	Sarcoplasmic Reticulum Calcium-Transporting ATPasesIBA 01/2019 - 09/2005
11	phospholambanIBA 02/2022 - 02/2002
11	Calcium-Transporting ATPases (Ca2+ ATPase)IBA 01/2020 - 09/2004
8	Protein Isoforms (Isoforms)IBA 08/2021 - 09/2002
8	salicylhydroxamic acid (SHAM)IBA 03/2017 - 09/2002
6	CalcineurinIBA 08/2021 - 11/2004
6	ChemokinesIBA 01/2018 - 11/2006
6	MicroRNAs (MicroRNA)IBA 01/2018 - 01/2011
6	Protein Phosphatase 1IBA 10/2017 - 04/2005
6	CollagenIBA 04/2016 - 09/2002
5	Isoproterenol (Isoprenaline)FDA LinkGeneric 02/2022 - 01/2012
5	MonocrotalineIBA 01/2020 - 07/2013
5	ResistinIBA 10/2018 - 08/2008
5	Pharmaceutical PreparationsIBA 01/2018 - 06/2009
5	Transcription Factors (Transcription Factor)IBA 12/2016 - 11/2004
4	Protein Kinases (Protein Kinase)IBA 08/2021 - 12/2010
4	RNA (Ribonucleic Acid)IBA 01/2020 - 05/2008
4	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 03/2016
4	Biomarkers (Surrogate Marker)IBA 01/2018 - 04/2009
4	Green Fluorescent ProteinsIBA 04/2013 - 02/2002
3	Adrenergic Agents (Adrenergic Drugs)IBA 10/2021 - 09/2010
3	Mitogen-Activated Protein KinasesIBA 08/2021 - 04/2013
3	Messenger RNA (mRNA)IBA 01/2020 - 08/2011
3	EnzymesIBA 01/2020 - 06/2002
3	Adenosine Triphosphatases (ATPase)IBA 02/2014 - 12/2002
3	Chemokine CXCL12IBA 03/2013 - 11/2006
3	Peptides (Polypeptides)IBA 01/2013 - 03/2007
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2020 - 10/2014
2	Semaxinib (SU5416)IBA 01/2020 - 01/2018
2	Sirtuin 1IBA 01/2019 - 12/2015
2	Ion Channels (Ion Channel)IBA 01/2019 - 01/2008
2	Hypoglycemic Agents (Hypoglycemics)IBA 01/2019 - 10/2013
2	CytokinesIBA 01/2018 - 01/2016
2	Galectin 3 (LGALS3)IBA 01/2018 - 12/2014
2	AntagomirsIBA 01/2018 - 04/2014
2	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 01/2018 - 03/2007
2	Chemotactic FactorsIBA 01/2018 - 11/2010
2	L-Type Calcium Channels (Dihydropyridine Receptor)IBA 08/2017 - 08/2012
2	Therapeutic UsesIBA 04/2017 - 12/2015
2	Angiotensin IIIBA 04/2016 - 01/2006
2	UbiquitinIBA 06/2015 - 11/2014
2	Stem Cell FactorIBA 01/2015 - 11/2012
2	Apolipoproteins E (ApoE)IBA 10/2014 - 03/2011
2	OligonucleotidesIBA 04/2014 - 09/2004
2	Brain Natriuretic Peptide (Natrecor)FDA Link 02/2014 - 07/2011
2	PeriostinIBA 01/2013 - 08/2007
2	Indicators and Reagents (Reagents)IBA 10/2012 - 10/2012
2	Small Interfering RNA (siRNA)IBA 01/2012 - 03/2009

Therapy/Procedure

53	Therapeutics 01/2022 - 08/2004
11	Ligation 01/2018 - 09/2002
7	Cutaneous Administration 02/2014 - 04/2009
4	Catheters 01/2018 - 10/2002
3	Cell- and Tissue-Based Therapy (Cell Therapy) 03/2017 - 01/2005
3	Heart-Assist Devices 02/2014 - 10/2008
2	RNAi Therapeutics 01/2019 - 03/2009
2	Injections 01/2018 - 01/2015
2	Heart Transplantation (Grafting, Heart) 01/2014 - 10/2008